The article “Bioorthogonally Cross-Linked Hyaluronan–Laminin Hydrogels for 3D Neuronal Cell Culture and Biofabrication” was published in Advanced Healthcare Materials today.
3D neuronal cell culture places stringent requirements on the materials. Here we present a hydrogel based on hyaluronan (abundant in the brain), crosslinked with laminin (important for neuronal adhesion and development). The gel supports spontaneous 3D differentiation of neural stem cells. It also proves suitable for protecting these cells during syringe extrusion, a key requirement for bioprinting as well as for therapeutic injection.