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New paper published in Science and Technology of Advanced Materials

The article “Astrocyte 3D culture and bioprinting using peptide functionalized hyaluronan hydrogels” was published in Advanced Healthcare Materials today.

3D neuronal cell culture places stringent requirements on the materials. Here we present a hydrogel based on hyaluronan (abundant in the brain), modified with small adhesion-cue peptides, and examine its ability to support astrocytic cultures. With a cyclic RGD peptide modification in particular, primary astrocytes interact well with the hydrogel in 3D culture. We moreover demonstrate 3D printing as a first step towards more advanced tissue constructs.