Our extensive review article “Personalized Models of Biological Barriers and Their Diseases: Recent Progress with Organs-On-Chips” was published in Advanced Biology today.
Barrier tissues such as epithelial and endothelial interfaces regulate molecular exchange, immune surveillance, and organ homeostasis, and their dysfunction contributes to diseases ranging from dermatitis to neurodegeneration. This work explores how organs-on-chips can better model these barriers by recreating flow, biomechanics, chemical gradients, and multicellular architecture, especially when combined with primary or iPSC-derived patient cells. By highlighting both shared principles and barrier-specific requirements, the review outlines how these platforms can advance patient-specific disease modeling, drug testing, and translational medicine.